JWH-073 is a synthetic cannabinoid (CB) that activates both the CB1 and the CB2 receptor (Ki = 8.9 and 38 nM, respectively).jwh 073 for sale,hu-210,jwh-073 side effects,jwh-018 high,jwh-018 and jwh-073,sales.jwh-018 ingredients,analgesic
This cannabimimetic compound has been identified in herbal blends. JWH 073 2’-naphthyl-N-(1-methylpropyl) isomer differs structurally from JWH 073 by having the naphthyl group attached at the 2’ position and a 1-methylpropyl group in place of a butyl chain.
The biological and toxicological properties of this compound have not been characterized.
JWH-073, a synthetic cannabinoid, is an analgesic chemical from the naphthoylindole family that acts as a partial agonist at both the CB1 and CB2 cannabinoid receptors. It is somewhat selective for the CB1 subtype, with affinity at this subtype approximately 5x the affinity at CB2.
The abbreviation JWH stands for John W. Huffman, one of the inventors of the compound.
On 20 April 2009, JWH-073 was claimed by researchers at the University of Freiburg to have been found in a “fertiliser” product called “Forest Humus”, along with another synthetic cannabinoid (C8)-CP 47,497.
These claims were confirmed in July 2009 when tests of Spice product, seized after the legal ban on JWH-018 had gone into effect in Germany, were shown to contain the unregulated compound JWH-073 instead.
The analgesic effects of cannabinoid ligands, mediated by CB1 receptors are well established in treatment of neuropathic pain, as well as cancer pain and arthritis. jwh 073 for sale,hu-210,jwh-073 side effects,jwh-018 high,jwh-018 and jwh-073,sales,jwh-018 ingredients.
These compounds work by mimicking the body’s naturally-produced endocannabinoid hormones such as 2-AG and anandamide (AEA), which are biologically active and can exacerbate or inhibit nerve signaling.
As the cause is poorly understood in chronic pain states, more research and development must be done before we can realize the therapeutic potential of this class of biologic compounds. jwh 073 for sale